Southampton scored twice in two minutes to deal a blow to Tottenham’s first four chances as they won a breathless 3-2 game in rain-soaked North London.
Spurs looked to be heading for the points in the final 10 minutes as an own goal from Jan Bednarek and an effort from Son Heung-min either side of Armando Broja’s strike gave them a 2-1 lead .
But headers from Mohamed Elyounoussi and Che Adams in quick succession turned the game upside down and handed the visitors the win, which on the whole was well deserved.
Ralph Hasenhuttl’s men, who felt Son’s goal should have been ruled out for a foul, had Spurs on the grid for the majority of the first half and they deserved the chance they had to see the equalizer from Steven Bergwijn’s stoppage time ruled out for offside.
They inflicted a first home defeat on Antonio Conte, whose side missed the chance to close the gap on the Champions League places to just one point.
There was a taste of what was to come only in the fourth minute as Adams squandered a big chance with a straight shot at Hugo Lloris from close range as Southampton started brilliantly.
Spurs came alive and saw a goal ruled out for offside as Cristian Romero was flagged following a free-kick header from Son before Sergio Reguilon missed a golden chance to open the scoring.
Lucas Moura started an electric break, which involved Son and Harry Kane, who attacked Reguilon, but the Spaniard fired straight at Fraser Forster.
But Forster took the ball back from his net moments later as another clever move put Spurs ahead in the 18th minute.
The ball was passed to Pierre-Emile Hojbjerg on the right and his low cross was turned into his own net by Bednarek with Son ready to pounce.
Southampton’s response was spirited and they nearly equalized from the kick-off as Broja hit the post after a touchline effort and then Lloris made a clever save to deny James Ward’s effort- Prowse to be within reach.
Spurs ignored their warnings and contributed to their own downfall as the Saints fought back in the 23rd minute.
Ben Davies inexplicably missed his kick trying to clear the ball into the box, that ended up with Romain Perraud, whose cross was sent home by Broja.
How Southampton failed to complete the game at half-time is a mystery as they had Spurs on the back foot and had an abundance of golden chances.
Stuart Armstrong’s header was cleared away by Lloris before Broja unnecessarily missed the target after charging into the net.
The onslaught kept coming as Perraud thundered an effort from long range against the crossbar, with Southampton finishing the first half with 15 shots on goal.
There was no way Spurs could be worse after the restart and they started to take control of the game.
Kane somehow missed a chance at the far post as he headed Reguilon’s cross too far into the ground and bounced off the crossbar.
Spurs pressure was finally revealed and they regained the lead in the 70th minute, but Southampton were furious.
They felt Broja had been fouled by Emerson Royal, but referee David Coote waved to play, Moura broke the right and crossed for Son to slide eight yards out.
There were heated arguments on the touchline as Broja received a lengthy treatment, with Conte having to be restrained by his staff.
Again Southampton responded well and were level 10 minutes later as Ward-Prowse sent in an accurate cross which Elyounoussi headed into the corner.
It was a carbon copy in the 82nd minute as this time Adams was at the end of Ward-Prowse’s excellent delivery.
Spurs thought they had equalized at the death but Bergwijn was slightly offside when he headed home Romero.